As a typical representative of generative artificial intelligence, Chat Generative Pre-trained Transformer (ChatGPT) is a natural language processing and machine learning developed model, which is launched by OpenAI, an American artificial intelligence research laboratory. Hardly had ChatGPT swept the world and generated a profound discussion around the world when it first appeared. Generative AI, represented by ChatGPT, as the latest achievement in AI development, is a significant step further toward, aiming the goal of designing sentient and general artificial intelligence. With the development of generative AI and its extensive application, it is believed to be reshaping human beings and human society, and humans will suffer unprecedented challenges while enjoying the convenience brought by the new technology, prominently manifested in the alienation of human beings by generative AI, reshaping human interactions, human thinking, and human labor. The study of human alienation in the information age requires an in-depth analysis of the phenomenon of human alienation with a historical materialist approach, starting from Marx's prescriptions on the nature of human beings, and finding a breakthrough to deal with the crisis caused by artificial intelligence. Human nature has a threefold connotation:first, interaction is a unique manifestation of human nature, second, thinking is a realistic expression of human nature, and third, labor is an intrinsic provision of human nature. With the rapid development of cognitive technology and neuroscience, generative artificial intelligence, with its unique simulation ability, exhibits a corroboration of the alienation of human nature as described by Marx, that is, human creations threaten the development of human subjectivity, including:the alienation of human interaction triggered by human-machine interaction, data-based interaction, and digital existence; human-machine combination, reliance on intelligence, and machine production bring about "transcendent" human beings, "weakened" human beings, and "void" human beings; the alienation of human and object, human labor, etc. In the face of the crisis of human alienation caused by generative AI, there is an urgent need for the return and revival of value rationality in the age of intelligence, an urgent need to correctly understand the value and limits of generative AI, and an urgent need to pay attention to the ultimate care for human life. Therefore, to deepen the reflection on human alienation caused by generative AI, one is to reconstruct the instrumental properties of generative AI, that is, to recognize that AI is only a human tool, to recognize the uniqueness of the tool, and to make good use of artificial intelligence as a tool. The second is to examine the value and limits of generative AI, that is, we must return to human self-value, realize the self-value of AI, and pay attention to the limit of AI development. The third is the natural purpose of generative AI development, that is, to build a controllable, safe and reliable AI.