In the context of the current accelerated evolution of the global economy, digital technology is increasingly becoming an important engine leading economic transformation and upgrading with its strong innovation driven ability and wide range of cross-border applications. As an important embodiment of new quality productivity, digital technology has not only profoundly changed the operation logic of traditional industries, but also provided unprecedented opportunities for the restructuring and innovation of cultural and tourism industries. The deep integration of digital technology and culture and tourism industry has promoted the iteration of culture and tourism consumption mode and the optimization of supply system, and has become one of the important ways to enhance urban economic toughness and enhance regional competitiveness. This paper first uses the entropy method to measure the digital technology and cultural tourism integration index of 284 prefecture level and above cities in China from 2011 to 2021, and explores the spatial-temporal differentiation pattern of their integration development level. Secondly, based on the dual perspectives of space and structure, Dagum Gini coefficient and variance decomposition method are used to investigate the size and source of the difference between urban digital technology and cultural tourism integration. Finally, the driving factors of the integration are revealed by using the method of geographical detector. The results show that: 1) The overall development level of digital technology and cultural tourism integration in China and the four regions as a whole has shown an obvious upward trend, but the spatial differentiation characteristics of digital technology and cultural tourism integration development among the four regions are obvious, and the spatial differences among the four regions show a distribution pattern of higher in the east, second in the middle, and lower in the west and northeast; 2) The spatial differentiation of the integration of urban digital technology and culture and tourism is mainly due to regional differences. The average difference between the eastern and central regions is the largest, while the average difference in the northeast region is higher than that in the eastern, central and western regions; 3) The main structure of the difference between digital technology and cultural tourism integration comes from the integration basis and scale; The contribution of integration basis difference is the highest in the central region, the contribution of integration scale difference is the highest in the eastern, central and northeast regions, and the development trend of integration efficiency difference is relatively stable in the four regions; 4) The explanatory power of the integrated development of digital technology and culture and tourism is in the following order: digital technology innovation>government support>economic development level>cultural development level>transportation infrastructure>ecotourism environment. Among them, digital technology innovation and government support are the leading forces of the integrated development of digital technology and culture and tourism; The development level of integration of digital technology and culture and tourism is affected by complex coupling of multiple factors. The best interactive factors are the level of economic development, government support and digital technology innovation. This study enriches and expands the evaluation scheme of the integration system of urban digital technology and culture and tourism, and provides an important reference for revealing the differential evolution of the integration of urban digital technology and culture and tourism in China, and exploring the two-dimensional collaborative improvement policy of space and structure.