During the social transition, selfattack is seen more often than not among college students. Selfattack is a form of emotional release for selfextrication at the sacrifice of the individual’s own living organism. Selfattack may results in physical injury or even loss of life, and is then referred to as extreme selfattack. Exploring the generation of college students’ extreme selfattack psychology and finding the effective preventive measures are of great practical significance for students’ healthy development and social harmony and stability, which is also a requirement from the humanbased educational concept. This article analyzes some statistical data on the college students extreme selfattack in China from 2004-2008, explores the direct and social causes of the behaviors and points out that the generation of college students’ extreme selfattack psychology is characterized by staged development, externalization, negation and controllability. The countermeasures for preventing college students’ extreme selfattack are proposed from the perspective not only of “cure the symptoms” but also of “cure the disease”.