Wenchuan Earthquake brought great loss to China’s education system. There are objective reasons of the destructiveness of earthquake, and also reasons of lack and imperfect of education emergency response mechanism when calamity happens. This thesis analyzes the influences of sudden natural calamity on education and education emergency response mechanism, the influence factors of education response mechanism strategy, the education response mechanism problems reveled in this earthquake and the disciplines of education system emergency response in sudden natural calamity and so on. It puts forward to establish education emergency response mechanism that combines early warming for sudden natural calamity, grade response and emergency response action, and deal with problems arising from an accident.