China’s foreign direct investment has shown the characteristics of regional non-equilibrium among the eastern region, central region and western region, and it has become an important factor which affects China’s regional economic differences. Through the introduction of Moran I index, the article analyzes the regional aggregation effect of China’s FDI. On this basis, with the help of Dunning’s location specific advantages theory, through the establishment of panel data model, this article analyzes the dynamic reasons for China’s FDI regional differences, and then sums up these reasons as quantity factor and quality factor. We should pay more attention to “quality” and realize the transform from quantitive FDI to qualitive FDI.