The entrepreneurship has become the new element for Chinese economic development. Based on the Chongqing 40 counties dynamic panel data in 2000-2008,this thesis uses GMM method to analyze the influence of entrepreneurship on Chongqing economic growth. The analysis result indicates that the entrepreneurship promotes Chongqing economic growth on average and has obvious positive hysteretic effect on economic growth. However,the influence of entrepreneurship on regional variation is considerable. The entrepreneurship sets back the economic growth of underdeveloped “two wings” regions,and nonproductive entrepreneurship is extremely active in these regions. Therefore,in the process of Chongqing economic growth,it should be well known the positive influence of entrepreneurship on economic growth. And Chongqing should establish the policy and institutional framework which is beneficial to implementing productive entrepreneurship and inhibiting unproductive entrepreneurial spirit.