Marx and Engels didn’t put forward the concept of “STS”, but their works contain rich content and profound thought of STS. STS thought of Marxism has double dimensions, outstanding performance in the dual role of science and technology to natural, social and human beings. Science and technology not only transform and utilize the nature, but also damage or even destroy nature. Science and technology not only promote the development and progress of society, sometimes will hinder social development. The development of science and technology not only promotes the liberation of the human beings, and will make them into a new “slavery”. The fundamental implication of STS thoughts of Marxism is: to overcome the negative effect of science and technology, and make science and technology coordinated development with the natural, social, human, fundamentally speaking, is not to eliminate the science and technology itself, but to transform the application environment of science and technology.