This paper introduces the ICA theory in the process of analyzing the entrepreneur mental factors which affect the value chain, and analyzes the feasibility of applying ICA theory in the extraction of the entrepreneur mental factors. In the empirical study, the authors separate the main factors influencing value chain by the FastICA algorithm based on ICA theory, and find that entrepreneur’s cognitive structure more significantly influences on the value chain. It is feasible to sift entrepreneur mental factors. The research results of this paper also provide a theoretical reference for the application of the ICA theory in value chain management and optimization.