This paper introduces the basic situation of input-output of China's science popularization. Combined with the actual situation of China's science popularization work, this paper constructs the input-output evaluation index system. By using method of DEA, the paper selects the science popularization statistic data from 2006 to 2013 to make the objective, scientific and effective evaluation on the input-output efficiency of China's science popularization. The preliminary study results proved that the input-output efficiency of China's science popularization should be improved further.