Curriculum-based ideological and political education is an effective channel to implement the spirit of the 20th CPC National Congress and promote the spirit to enter the mind, the heart, and the conduct. Integrating the spirit of the 20th CPC National Congress into ideological and political teaching in an all-round way, and educating and guiding college students to firmly grasp the great significance of great changes, scientific world outlook and methodology, the mission of national rejuvenation and the requirements of the times of unity and struggle, are not only the political requirements of the sustainable development of the Party and the country, but also the requirements of the times for new people to grow into talents, and the practical requirements for improving the quality and efficiency of the ideological and political teaching of the course. Integrating the spirit of the 20th CPC National Congress into curriculum-based ideological and political education mainly includes the great achievements of the new era in the past ten years, Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era’s world outlook and methodology, the mission of promoting the great rejuvenation of the Chinese nation with Chinese path to modernization, the major policy of the development of the cause of the Party and the state in the new period, the latest requirements of the Party and the state, etc. To promote the integration of the spirit of the 20th CPC National Congress into curriculum-based ideological and political education, we should adhere to the principle of integrating learning with thinking, uniting knowledge, belief and practice, and effectively improve the systematization, effectiveness, academic rationality and practicality of integration. First, grasp the principles of systematicness, organicity and practicality, and practically improve the systematization of integration. Grasp the systematic principle of integration, make overall planning, classified implementation, coordinated promotion and open development, and integrate into curriculum-based ideological and political education system as a whole. Grasp the organic principle of integration, embedding "gene" into textbooks, "ecological" into lesson plans, "chemical formula" into teaching methods, and scientifically integrating into the ideological and political teaching system. Grasp the practical principle of integration, integrate practical resources, enrich practical content, promote practical teaching reform, improve support mechanism, and effectively integrate into curriculum-based ideological and political education. Second, closely follow "melting materials", "melting points" and "melting machines" to effectively improve the effectiveness of integration. Closely follow the development history, struggle history and contribution history of various disciplines and specialties in the past ten years of the new era, the outstanding examples and spiritual pedigree of each discipline and specialty in the past ten years of the new era, and the role orientation of each discipline and specialty in the great cause of building a socialist modernized country, and select "melting materials". Closely follow the educational objectives of public basic courses, professional education courses and practical courses, and find out the "melting points" such as the focus, emphasis and foothold of integration. Pay close attention to students’ hot spots, ideological blocking points and emotional boiling points, and grasp the "melting machine" to solve "confusion of thoughts", "blocking of hearts" and "emotional distress". The third is to stress "truth", "academic theory" and "philosophy", and effectively improve the academic rationality of integration. Seize the question of the times and deepen the "truth" of the spirit of the 20th CPC National Congress. Combining with academic logic, thoroughly explain the "academic theory" of the spirit of the 20th CPC National Congress. Integrate into real life, and make the "philosophy" of the 20th CPC National Congress alive. Fourthly, internalize, externalize and transform, and improve the practicality of integration. Guide students to internalize the spirit of the 20th CPC National Congress and strengthen their ideals and beliefs. Encourage students to externalize the spirit of the 20th CPC National Congress and practice their excellent skills. Encourage students to turn the spirit of the 20th CPC National Congress into responsibility and strengthen their mission.