The formation process of enterprise core competitiveness is the process to satisfy customer value. This article built the dynamic CRO enterprise core competitiveness evaluation index system combined with the CRO enterprise internal and external ecological based on four stages at which CRO companies satisfy customer value, namely, analyzing, creating, achieving and satisfying customer value. This article compares the gap between a domestic CRO and a Foreign Investment CRO Enterprise after empirical evaluation on the enterprise's core competitiveness by using the grey fuzzy evaluation method, to provide reference for the promotion of core competitiveness of the domestic CRO enterprise.