Abrasive belt grinding experiments of Zr-4 nuclear power tube are carried out by using three different abrasive belts with same size, and the interactive generating mechanism between abrasive and workpiece is analyzed, the main factors of material removal rate and surface roughness of Zr-4 alloys are obtained. With the help of the advanced test facilities, the abrasive grain abrasion and surface topography of the workpiece are observed. The metallographic structure and microhardness of the layer of burnt surface during Zr-4 alloys Grinding are analyzed. Some conclusions are given as follows: the material removal rate and surface roughness are mainly affected by the factors of belt speed, grinding pressure, hardness of the contact wheel and abrasive type, of which, the belt speed is the strongest factor. The adhesion wear of the Zirconium corundum and aluminium oxide abrasive grit is more serious, the most important wear form of silicon carbide is abrasion wear. With the onset of grinding burn, the mechanical properties of Zr-4 alloys are deteriorated obviously. The results provide a theoretical and experimental basis for technical optimization in the grinding of Zr-4 alloys with efficiency and high quality.