On the research of alternative refrigerants, because of their advantageous thermal characters and unparalleled prepondrance of environmental protection, kinds of HCs substance have taken more and more scholars attention. At the base of full demonstration, the HCs is applied on large-scale screw-refrigerator for the first time. The result indicate that, although the autlwrs do not make any better about the system, the energy-efficiency-ratio(EER) of R290 system is equally matched R22 system. So R290 can alternate R22 in the refrigerant system and can works well. If some improvements are maken on the system against the flammability of HCs, then the large-scale refrigerant system with HCs as the refrigerant could march to the markets, and make immense social and economic benefits.