细胞的力学特性与细胞的结构和功能密切相关，细胞粘弹性是细胞的一种本质属性，也是细胞力学特性研究的重要内容，微吸管法是一种在单个细胞水平上研究细胞力学特性的先进手段。为探讨微吸管研究肝癌细胞力学特性的理论和方法，采用连续介质力学的手段，把肝癌细胞看作是均匀的连续体，考虑到肝癌细胞在形态和结构上与白细胞没有明显差别，有相似的力学行为，选用标准线性固体模型描述肝癌细胞的粘弹特征，建立了微吸管法研究肝癌细胞粘弹性的理论模型，为这一领域的相关研究提供方法学参考和借鉴。

The mechanical properties of cells are relation to their structure and function. Viscoelasticity is a kind of essence properties of cells and an important researching contents in the field of cellular mechanics. Micropipette aspiration technology is an advanced artifice on the level of single cell to study the mechanics of cells. In order to investigate the theory and method in researching mechanical properties of hepatocellullar carcinoma cells with micropipette aspiration, hepatocellullar carcinoma cells was regarded as an even linear solid and the standard linear solid viscoelastic model was chosen to describe viscoelasticity of hepatocellullar carcinoma cells, theory model of viscoelasticity of hepatocellullar carcinoma cells by micropipette aspiration was established according to the related papers, it will provide methodology reference for studies in this fields.

R735.7 R730.21

国家自然科学基金资助项目 ( 19972 0 77)