The research on the remodeling in mandible under the action of orthopedic loads is important for the determination of orthopedic scheme. a three-dimensional finite element model of mandible and temporomandibular joint is established. Using Cowin Remodeling Law, the finite element simulation of the remodeling in mandible during the orthopedics under the action of orthopedic loads is carried out. Comparing the numerical results after remodeling with those before remodeling, it is demonstrated that the normal remodeling greatly affects the distribution of strain and strain gradient on the surface, therefore the effect cannot be ignored in the determination of the orthopedic scheme.