Desulfuration process is a very sophisticate reaction which is not only diverse but also non-line. A RBF algorithm based on generalized genetic optimization is proposed after studying the standard genetic and RBF algorithm. The authors also introduce its application in prediction Model for molten Iron Desulfuration. The algorithm perfectly resolve the problem of random selection of RBF cluster center number. Furthermore, it also reduces the time which GA uses. Comparison between the simulation results of RBF and RBF algorithm Based on GGA optimization further proves the efficiency and precision of its application in Prediction Model for Molten Iron Desulfuration. Finally the result of the test shows that after adopting the algorithm, the end-point hitting ratio can reach eighty-five percent. This indicate the algorithm has the engineering practicability.