国家自然科学基金资助项目(20675064); 重庆市自然科学基金资助项目（CSTC2005BB4100）
研制了盐酸格拉司琼离子选择性电极。利用正交设计法综合研究了活性物质的含量以及增塑剂等因素对PVC膜电极响应性能的影响。结果表明，以盐酸格拉司琼四苯硼钠离子缔合物(膜中含量为4.8 %)为活性物质，邻苯二甲酸二辛酯为增塑剂制成的PVC膜电极的性能最佳。该电极在5.0×102～1.0×105 mol·L-1范围内呈现能斯特响应，斜率为58.7 mV/pc，检测下限为8.0×10-6 mol·L-1。该电极可直接用于盐酸格拉司琼片剂的含量测定，回收率为99%～102%，其结果与高效液相色谱法一致。
A granisetron hydrochloride selective electrode is prepared based on granisetrontetraphenylboron as a carrier . Orthogonal methodology is adapted for studying the impacts of active substance content and Plasticizer on response performance of PVC Membrane Electrode. The option of Granisetron hydrochloride Sodium Tetraphenylboron IonAssociation Compounds(4.8% in membrane) as active substance and Dinoctyl phthalate(DOP) as Plasticizer is the best scheme. A fast nearNernstian response is shown for granisetron of 5.0×10-2～1.0×10-5 mol·L-1 with the slope of 58.7 mV/decade. The detection limit is 8.0×10-6 mol·L-1 and the electrode can be used for potentiometric determination of granisetron hydrochloride tablets directly. The recovery range is 99%～102% which is in agreement with those determined by the method in the Pharmacopoeia.
曲中堂,袁若,柴雅琴,叶光荣.高选择性5HT3受体拮抗剂盐酸格拉司琼离子选择性电极的研制与含量测定[J].重庆大学学报,2009,32(8):979-982.
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