FEM/BEM (Finite Element Method/Boundary Element Method) mode analysis of the noise radiation from motorcycle engine shell is conducted. The natural frequency is compared between FEM/BEM analysis and experimental analysis. The FEM/BEM results are agreed with the experiment results, which proves that the finite element model is correct. The frequency response is analyzed and the structure’s noise radiation is simulated by means of FEM/BEM, in order to predict the noise radiation from the motorcycle engine shell and gain the sound field characteristic outside the structure. The calculation data is compared with the experiment data in different frequency bands. The result shows high accordance, which indicates that this method is effective.