A comprehensive evaluation method based on fuzzy matter element analysis is proposed to solve problems of multiple performance and quality evaluation for computer numerical control (CNC) equipment. The fuzzy matter element theory is utilized to analyze multi-scale quality characteristics and attributes. Then, the comprehensive quality evaluation model for CNC equipment is founded by using fuzzy matter element analysis method. Analytic hierarchy process (AHP) and information entropy are applied to obtain the objective index weights. Furthermore, the combinational weight is calculated with the optimal mathematics model based on the least square method. Finally, the fuzzy matter element method is used to determine the assessment result. The case study indicates that the method has a certain rationality and feasibility.