Electromagnetic radiation, which is caused by the engine ignition system, is the most powerful electromagnetic interference (EMI) source in the vehicles, as well as the main reason of most electronic control unit (ECU) malfunction. In order to reduce interference from ignition noise on ECU, we use optical isolation technology to isolate electrical connections between the interference source and the control circuit. The formation mechanism of the ignition system EMI is analyzed. The possibility of suppressing ignition system EMI with optical isolation technology is discussed. Then, as a result we design an experimental platform of suppressing ignition system EMI. The experimental results show that the effect of suppressing ignition noise, in 20~100 MHz frequency band, is obvious after applying optical isolation circuit. It can address the issue of automotive EMC.