In order to research the offshore wind turbine which operates in harsh environment with transient and variable working conditions, the system is simulated and analyzed by simulation technology. The aerodynamic load of wind turbine is calculated by applying GDW theory and wave load is calculated by applying Airy wave theory. The drive chain is programmed in Matlab/ simulink and the flexible multi-body model of the wind turbine is built in Adams. The combined simulation of the wind turbine is carried out. The results of a 5 MW offshore wind turbine show that the method has excellent ability to simulate the performance almost the same as software Bladed result.