To solve the problem of low control accuracy and low stability of current X-ray machines, a kind of digital power supply for X-ray machine is introduced. In the digital power supply, some key technologies are used to improve the output stability of the high frequency inverter, including improved BUCK circuit for voltage regulating circuit, high frequency inverter and soft switching technology for the high-voltage generator. The PWM control technology is used to control the switch transistor of voltage regulating circuit and inverter circuit, which makes the drive waveform output stable and easy to control. In order to improve the control accuracy, reduce the volume and change high voltage consecutively, the software PID of the microcomputer is used to control the feedback circuit. The high-accuracy power chip is used for the filament power supply to make the filament electric current stable. Through the analysis of the circuit, the parameters of the circuit are calculated and the circuit is simulated by PSPICE software. The results show that the theoretical analysis is consistent with the practical simulation results. The design can meet the requirement of the technology indices of the power supply of the X-ray machines.