High temperature mechanical properties are key factors which affect fracture production during deforming process of continuous casting. High temperature properties of weathering steel Q450NQR1 are tested in 3 cooling rates (1.65, 5, 10 ℃/s) using Gleeble thermo-mechanical simulator. Specimens appear austenite dynamic recrystallization at 1 050 ℃， and the ductility reaches the lowest point and the reduction of area approaches 23% at 850 ℃ in 3 cooling rates. As the cooling rate increases, the low ductility area where cracks are easy to be produced in slabs is enlarged and extended towards low temperature, and the ductility troughs are deepened. The increase of the cooling rate decreases the tensile stress and yield stress, while when the cooling rate increases to some degree, it doesn’t affect the stress. The low cooling rate decreases the film or network ferrite producing in austenite grain boundary, and the carbonitride of microalloy is enwrapped in matrix, which is helpful to improve the ductility of steel.