Gas drainage from boreholes is main method of utilization and management of Chinese coal seam gas. As the exploitation depth increases, stress field and other factors on the impact of gas seepage are increasingly apparent. Based on the basis of a series of assumptions of coal seam gas, porosity and permeability equations are described by considering stress, coal seam gas pressure change on the coal produced by deformation of the skeleton. The fluid-structure coupling equations are derived by using the basic theorem of porous media flow and the fluid structure coupling theory. The gas seepage field is simulated and analyzed by using multi-physics coupling analysis software. The effect of gas pressure distribution, different burial depths and different drilling parameters (drainage negative pressure, drilling radius) on gas seepage field is obtained. Analysis of simulation results can provide theoretical guidance for on-site gas drainage.