The influence of different factors on dissolution rate of rock salt is studied by a series of experiments, such as dissolution obliquity, solution concentrations, solution temperatures and solution flows. The laws of rock salt dissolution shown in the experiments are as follows: it isn’t obvious that the effect of the dissolution rate on different dissolution area. Temperature, velocity of flow and dissolution obliquity is in an exponential relationship with rock salt dissolution. Dissolution rate decreases with the increase of solution concentration of rock salt. Gray correlation analysis is adopted to study the dissolution obliquity, solution concentration, temperature and solution flow rate. It is found that solution temperature is the main factor, followed by dissolution obliquity, solution flow rate, and solution concentration. The findings can provide theoretical foundation and experimental basis for rapidly create cavity.