The measured data of grounding grid corrosion diagnosis are often influenced by steel structural frames, and thus the diagnosis is inaccurate. Based on grounding grid corrosion diagnosis theory, the characteristics of structure frames number, length, layout location and resistance of the influence on the diagnosis result are analyzed by establishing the simulation model. The results show that regardless of the structural frames’ number, layout location and span length, the existence of structural frames reduces the diagnosis sensitivity of fault branch which is near structural frames, making the extent of diagnosed branch corrosion is lower than that without framing. However, the diagnosed corrosion of the branch which is away from the structural frames won’t be influenced. The bigger the resistance of the structural frames connected to grounding grid, the smaller the diagnosis result of interference. Choose the grounding grid branch which has no obvious increase multiples near structural frames as excavation object can improve the diagnostic accuracy.