The treatment efficiency of mustard comprehensive wastewater with high salt by electro-Fenton is studied to solve the problem that microorganism is inhibited by high salt and improve the unstable performance of biological treatment. CODcr removal effect and its influencing factors in high salt wastewater by electro-Fenton process are mainly investigated, and the degradation kinetics of CODcr is analyzed. The results show that CODcr removal rate reaches 76.33 % after 120 min at the conditions that current density of 10 A/dm 2, ferrous sulfate dosage 1.0 mmol/L, electrode spacing 15 mm, pH=5, RuO2-IRO2-SnO2-TiO2/Ti quaternary as anode, titanium mesh as cathode. Kinetic analysis shows that the degradation curve of CODcr consists with the first-order response characteristics and the value of the kinetic constant is 0.0121 min -1 when COD of raw wastewater is 4 225 mg/L. By linear regression equation, kinetics model of CODcr degradation is established. The model possesses higher regression rate (R 2=99.25%) and has higher coincide degree with the experimental results.