In order to predict the physiological and pathological conditions of the humans, the study of hemodynamics information of arterial pulse wave is very important and valuable in cardiovascular. Regarding the blood vessels as a number of small flexible pipes in series, a electrical circuits model of the upper limb is presented according to Windkessel theory. Using Simulink and Simpowersystem of the matlab, the waveform of pressure can be simulated by the electrical circuits model. In view of hypertension and atherosclerosis is reflected by variations of dynamic parameters, we obtain waveform of the radial pressure and flow after simulation, and analyze the influence on pressure waveform in radial artery when the peripheral resistance and the compliance of the vessels changes respectively. These waveforms accord with the real physiological conditions, therefore the results show the effectiveness and validity of the model.