To study the effects of different oxygen blast furnace operating procedures and their operating parameters on blast furnace process, and to predict the variation of each parameter of oxygen blast furnace process, a multi-fluid blast furnace model is built based on multi-fluid theory, metallurgical transport theory, metallurgical thermodynamics and kinetics, and computational fluid dynamics. By modifying its boundary conditions and internal parameters, the establishment of multi-fluid model of oxygen blast furnace is achieved. Numerical simulation of the normal blast furnace and gasification furnace-oxygen blast furnace (GF-FOBF)is carried out with this model and the fields of typical parameters, such as temperature field, are obtained. By comparing the calculation results, the main features of the furnace under oxygen blast furnace operating conditions and changes relative to the traditional blast furnace are analyzed. It can be found that the oxygen blast furnace internal velocity field and temperature field change, especially the distribution of gas. This model can provide reference for the experiment and development of the oxygen blast furnace process.