浙江省新苗人才计划资助项目（2016R436010）。
以甘氨酸（Gly）和磷钨酸为原料合成的一系列无机有机杂化材料为催化剂，考察各因素对其催化合成乙酸异戊酯的影响，并利用响应面分析法优化乙酸异戊酯合成工艺。研究表明，[GlyH]1.0-H2.0PW12O40催化剂具有最高的催化酯化反应活性和重复使用性能。响应面分析法优化乙酸异戊酯合成的最佳条件为：醇酸摩尔数比为1.05：1，催化剂用量为酸质量的4.5%，反应时间2.0 h，带水剂量10 mL，该条件下，乙酸异戊酯产率为98.5%，结果与模型预测值基本相符。优化条件下[GlyH]1.0H2.0PW12O40催化酯化反应表观活化能为79.73 kJ/mol。
The organic-inorganic hybrid catalyst,namely[GlyH]xH3-xPW12O40(x=1.0-3.0),was prepared by combining phosphotungstic acid and glycine (Gly).The effects of various factors on the catalytic synthesis of isoamyl acetate with using[GlyH]xH3-xPW12O40(x=1.0-3.0) as catalysts were studied,and the synthesis process of isoamyl acetate was optimized by response surface methodology (RSM).The results show that[GlyH]1.0-H2.0PW12O40 catalyst has the highest catalytic esterification reactivity and reusability.The optimum conditions are n(isoamylol):n(acetic acid)=1.05:1,the amount of catalyst to acetic acid 4.5%,reaction time 2.0 h and water-carrying agent 10 mL.Under these conditions,the yield of isoamyl acetate reaches 98.5%,which is in basic agreement with values predicted by the mathematical model.Under the optimal conditions,the active energy of the esterification is 79.73 kJ/mol.
梁娟娟,赵宇钱,李芳浩,韩晓祥,方苗利.无机-有机杂化材料催化合成乙酸异戊酯及动力学研究[J].重庆大学学报,2017,40(6):86-94.
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