According to relevant surveys, S content of Panzhihua titanium concentrate is as high as 1.55%. We studied the effects of sulfur on the smelting of titanium slag in Panzhihua titanium concentrate. The results show that smelting Panzhihua titanium concentrate to produce titanium slag, the S content of the by-product semi steel is higher, and the C content is lower. Furthermore, the temperature of molten metal increases by an amplitude of 70℃ to 150℃, and the power consumption per ton slag increases by nearly 20 kW·h. By comparison, producing titanium slag by smelting titanium concentrate after oxidative desulfurization can reduce the content of S and eliminate the influence of S on the smelting process. Therefore, pre-oxidation is an effective way to produce titanium slag with high-sulfur titanium concentrate.