In order to study the influence of transmission tower-foundation-bed coupling effect (SSI interaction) on wind-induced response of transmission tower under wind load, an UHV transmission tower-foundation-bed system is taken as an example to design its aeroelastic model according to discrete stiffness method with a rigid mass block used to simulate the foundation, and U-spring and damper used to simulate the bed to test the aeroelastic model in wind tunnel. The influence of foundation damping and stiffness on wind-induced response of transmission tower structure is also studied. The experimental results show that: 1) with SSI interaction taken into account, the vibration attenuation of the model is slower than that of the rigid foundation model; with the decrease of the foundation stiffness, the comprehensive stiffness of the model decreases and the natural vibration period increases; 2) the reduction of the foundation stiffness will gradually lead to greater displacement and acceleration response of the superstructure, but have little effect on the reaction force of the tower foot; with the increase of the foundation damping, the acceleration of the tower body decreases gradually, but the displacement and the reaction force of the tower foot almost remain unchanged. In conclusion, the influence of SSI interaction should be considered in the design of transmission tower structure.