In order to further improve the measurement accuracy of high mobility precision measuring equipment such as articulated arm CMM,the D-H matrix method the mathematical model of joint coordinate transformation and the parameter error model is derived accordingly.the problem of nonlinear multiparameter calibration, the redundant parameters in the matrix are eliminated by transformation analysis, the complexity of calculation.criteria for judgment and the mixture of least square method and simulated annealing algorithmA new method of parameter calibration based on hybrid optimization algorithm is proposed, which solves the problem of initial value setting of LM algorithm and search efficiency decreasing of SA algorithm.The experimental results show that the error range of the parameters of the articulated arm measuring machine is significantly reduced after the parameters are calibrated by the hybrid optimization algorithmhe average value of single point repeatability error is reduced by 1.746 mm, and the average value of length error is reduced by 0.941 mm. The measurement error is further suppressed.