The load carrying capacity of locally compressed I-girders with rectangular concrete-filled tubular flange and corrugated web (RCFTFG-CW) is investigated through numerical simulation method. Finite element (FE) models of steel I-girders with rectangular concrete-filled tubular flanges and corrugated web and corresponding I-girders with flat-plate flanges and corrugated web (IG-CW) under concentrated load at mid-span are built. The reliability of the presented FE models is verified through comparing the FE results with reported experimental results. Through FE analyses by using the FE models, local compressive strength, stress development, and effect of loading location on the strength are analyzed and compared. The influences of variation of geometric parameters, material properties, load distribution length (along the span of girder) and the ratio of the stretched length of the wave to the wave length on the local compressive strength are further investigated. Based on parameters analysis, formula for calculating the local compressive strength of RCFTFG-CW are proposed, and the accuracy of the formula is verified by the results of finite element analyses. The results indicate that RCFTFG-CW has a higher local compressive strength compared to that of IG-CW. The local compressive bearing capacity increases proportionally to the equivalent moment of inertial of the concrete-filled tubular flange to the 1/4 power, the thickness of the web, the ratio of the stretched length of the wave to the wave length and loading length. The presented formula are proved to be accurate to predict the local compressive strength of RCFTFG-CW.