The irreversible electroporation technique has demonstrated remarkable efficacy in tumor treatment. Recent studies indicate that combining high-voltage nanosecond pulses with low-voltage microsecond pulses can significantly improve ablation effectiveness. To address this, this paper proposes a novel topology for a synergistic pulse generator, consisting of two Marx circuits utilizing insulated-gate bipolar transistors(IGBT) and metal-oxide-semiconductor field-effect transistors(MOSFETs) as main switching devices. By flexibly controlling these switches, the generator can produce a synergistic pulse sequence comprising high-voltage nanosecond pulses and low-voltage microsecond pulses. This study explores the generator’s operating principle, circuit simulation, and prototype development. The resulting all-solid-state synergistic pulse generator features flexible and adjustable parameters, leveraging semiconductor switches for improved performance. Its functionality is evaluated using a 100 Ω resistance load, yielding the following pulse characteristics: nanosecond pulses with voltage amplitudes of 0 kV to 15 kV and pulse widths of 200 ns to 1 μs, and microsecond pulses with voltage amplitudes of 0 kV to 5 kV and pulse widths of 10 μs to 100 μs. These parameters meet the experimental requirements for synergistic pulsing in tumor ablation.