Fatigue-creep interaction tests were conducted on Ti60 alloy specimens at 550 ℃. Under test conditions of maximum fatigue stress σ_max=450 MPa and stress ratio R=0.1, the influence of different creep stresses on the fatigue-creep behavior of the alloy was investigated. Based on the test data and the Norton model, a novel method was proposed to improve the understanding of fatigue-creep behavior with a limited number of samples. This approach establishes a prediction model capable of estimating the threshold value of creep stress over extended periods through short-term experimental data. The model’s predictions were compared with results from the maximum axial stress method and the step-loading method, yielding a relative error of less than 2%. The results show that the proposed prediction model can accurately determine the creep stress threshold under fatigue-creep interaction conditions.