不可逆电穿孔肿瘤治疗技术已经在临床应用中取得了较为显著的疗效。最近研究表明,采用高压纳秒脉冲协同低压微秒脉冲可以显著提高消融疗效。因此本文提出了一种新型的协同脉冲发生器拓扑结构,主要包括两个分别由IGBT和MOSFET作为主开关的Marx电路。通过开关的控制可灵活输出由高压纳秒脉冲和低压微秒脉冲组成的协同脉冲序列,并对其工作原理、电路仿真及原型样机进行了研究。最终采用半导体开关研制了一款参数灵活可调的全固态协同脉冲发生器,并在100Ω电阻负载上对其进行了性能测试,纳秒脉冲参数为：电压幅值0-15kV、脉宽200ns-1μs；微秒脉冲参数为：电压幅值0-5kV、脉宽10μs-100μs,能够满足协同脉冲消融肿瘤的实验需求。

The irreversible electroporation tumor treatment technique has already achieved remarkable efficacy in clinical application. And recent studies have shown that the use of high-voltage nanosecond pulses in combination with low-voltage microsecond pulses can significantly improve the ablation efficacy. Therefore, this paper proposes a novel topology of synergistic pulse generator, which consists of two Marx circuits with IGBT and MOSFET as the main switches respectively. Through the flexible control of the switches, the synergistic pulse sequence composed of high-voltage nanosecond pulse and low-voltage microsecond pulse can be output. The operating principle, circuit simulation and prototype of the synergistic pulse sequence are studied. The result is an all-solid-state synergistic pulse generator with flexible and adjustable parameters by using semiconductor switches. And its performance was tested on a 100Ω resistance load. The nanosecond pulse parameters are as follows: voltage amplitude 0-15kV, pulse width 200ns-1μs. The microsecond pulse parameters are: voltage amplitude 0-5 kV, pulse width 10 μs-100 μs, which can meet the experimental requirements of collaborative pulse ablation of tumor.

TN78; TM832

国家自然科学基金青年科学基金项目(51807016, 51907011)，重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0932)，中央高校基本科研业务费(2020CDJYGSX001, 2020CDJYGDQ008)，重庆市高等教育教学改革研究项目(213052)，重庆市研究生科研创新项目（CYB22016）