High single consumption of zinc powder and low cadmium content in purified cadmium removal residue are common problems in zinc sulfate solution zinc powder replacement for cadmium removal, and the core reason is that zinc powder is wrapped by the product layer to reduce its reactivity.Based on this, a new method for countercurrent replacement of two-stage zinc powder in enhanced zinc sulfate solution by mechanical activation was proposed, and zinc powder with a lower coefficient was added to produce advanced cadmium in the first stage, and zinc powder with a higher coefficient was added in the second stage to control the cadmium content in zinc sulfate solution to meet the quality requirements of solution purification. The results show that under the conditions of total zinc powder addition coefficient of 1.02, reaction temperature of 60°C and reaction time of 60min, when the addition coefficient of primary zinc powder is 0.9 and the addition coefficient of secondary zinc powder is 1.2, the concentration of cadmium in the liquid after primary purification is reduced from 1530mg/L before reaction to 60~70 mg/L, and the cadmium content in the cadmium residue produced by primary purification is enriched to 81.54%, and the zinc content is less than 10%. After secondary purification, the concentration of cadmium in the solution was reduced to 2~5 mg/L, and the cadmium content in the purification residue was 16%, and the zinc content was 55%. The main phase of the primary purification residue is elemental cadmium, and the main phase of the secondary purification residue is unreacted zinc and some elemental cadmium. Compared with the traditional primary purification process, through the shear stress and mechanical activation of the fluid, the wrapping layer on the surface of the zinc powder is destroyed, the wrapping phenomenon on the surface of the zinc powder is eliminated, the utilization efficiency of zinc powder is improved, the consumption of zinc powder is reduced, and the cadmium content in the purification residue is improved.