Considering the structural characteristics and internal and external excitations of offshore wind turbines, a rigid-flexible coupled multi-body dynamic model for large wind turbines is established. A comprehensive performance evaluation method for wind turbines is proposed based on the interpretive structural model and the analytic network process. A comprehensive performance evaluation framework for wind turbines is built, including five primary indicators and 11 secondary indicators. An interpretive structural model is adopted to analyze the inherent connections between indicators. Following this, a multi-layer hierarchical structural model is produced to evaluate the comprehensive performance of wind turbines. The analytic network process is used to construct judgment matrices, hypermatrices, and extreme hypermatrices. The weights of comprehensive performance evaluation indicators are solved. Following this, the comprehensive performance of the wind turbine is quantitatively evaluated, and the comprehensive performances of the two models are compared and analyzed. The results show that the main factors affecting the comprehensive performance of wind turbines are blade length, bearing time-varying reliability, gear contact fatigue reliability and unit megawatt weight. The comprehensive performance of 5MW wind turbines is better than that of 6.2MW wind turbines.