The comprehensive performance of the lithium battery thermal management system is very important to the capacity and operating life of the battery. In order to improve the comprehensive performance of the lithium battery thermal management system after packaging, a new liquid cooling plate cooling structure based on a double-channel tesla valve is proposed. Firstly, the comprehensive performance of the same side outlet and different side outlet of the liquid cooling plate coolant is compared by numerical simulation, and the comprehensive performance of the double-channel tesla valve is compared with the original tesla valve and the DC channel. Then the orthogonal test method is used to screen out four parameters that have a greater impact on the comprehensive performance of the double-channel tesla valve. The Kriging response model between the design variable and the objective function is established, and the second generation non-dominated sorting genetic algorithm (NSGA-Ⅱ) is used for multi-objective optimization. The results show that the comprehensive performance of the liquid cooled plate with different side inlet and outlet is better. Compared with the DC channel, the maximum battery temperature (Tmax) of the double-channel tesla valve cold plate structure is reduced by 0.67℃ in the countercurrent condition, and the flow channel pressure drop (Δp) is 117.67Pa and 437.39Pa lower than that of the original tesla valve and the DC channel. Compared with the initial double-channel tesla valve, the optimized new tesla valve flow channels corresponding to ΔT and Δp are reduced by 1.52% and 11.16%, respectively, and the overall performance (CTPF) is improved by 4.81%. This study provides a reference for the structural design and optimization of power battery cooling runner.