In order to study the mode that the Regional Innovation Network (RIN) influence to the regional industry innovation, Firstly, the key factors of RIN have been put forward from the view of innovation. Manners of regional industry innovation have been divided into two kinds: to create new ability and to create new industry. Second, the influence of each key factor of RIN to the two kinds of innovations has been studied respectively. After that, the modes that RIN influence to the regional industry innovation are concluded with the numbers systematically. The result indicates that to study the two ways of industry innovation form the visual angle of RIN' key element respectively can announce the influence that RIN to the regional industry innovation more scientifically. It can also offer the theoretical foundation for the government to improve the innovation ability in the area through optimizing RIN. At last, taking the 128 highways of industry's gardens in U.S.A. as the case, the authors validates the conclusion above-mentioned, and they give several suggestions to the regional industry innovation.