Several destruction methods of chemical and biological warfare agents are summarized, high-temperature destruction of Chemical Agent conventionally including incineration, plasma pyrolysis, hydrogenolysis, supercritical water oxidation, supertropical Bleach and Low-temperature decontamination of chemical agent involving hydrolysis, reaction using amines, electrochemical oxidation, solvated electron technology, photochemistry oxidation, non-aqueous substitution et al. In actual combat, high-temperature incendiary, SNL foam may be employed. To neutralize deep-buried chemical and biological weapon, nuclear agent-defeat method might be adopted, low-yield nuclear explosion will bring high-temperature,high pressure and strong radiation, with these effects chemical and biological warfare agents may be effectively destroyed in situ, the casualties from these effects would be fewer than those from the dispersal of large quantities of bioagents.