A twodimensional gray image of the material fault can be obtained without destruction by industrial computer tomography (ICT). This process is used to distinguish the seizure and the expansion of cracks within the initiation section. A fatigue life prediction method based on industrial CT images was studied. First, the crack initiation and expansion processes were divided into three phases: microscale thinness sight crack, CT scale crack, and macroscopic crack. Second, different crack initiation and expansion standards were adapted to calculate material fatigue life. The fatigue life of the material was the sum of the three phase's fatigue lives. Compared with other methods, such as the fatigue cumulative damage theory method and the nominal stress method, the fatigue life predicted by this method is more precise.