In order to solve the problem that urine sediment visible components cannot be segmented effectively because of complex components, complicated defocusing in image and poor discrimination between object and background, a method based on combination algorithm wis designed to segment urine sediment. The wavelet transform wis used to erase the effect of defocusing. Then morphology wis utilized to get the subimages that include the particles. The segmentation method combining the wavelet transform based segmentation and the twodimensional entropy threshold based segmentation wis employed to segment urine sediment visible components. Experimental results show that the proposed method can segment urinary sediment images effectively and precisely.