Based on the existing research on nozzle arrangement method in secondary cooling zone of continuous casting, the method of superposed water flow density is put forward to optimize the nozzle arrangement at casting direction and transverse section of slab according to the optimization principle. The two-dimension heat transfer model is established. The solidification morphology of cross-section at casting direction is simulated with consideration of the influence of water flow density inhomogeneity on solidification process at transversal section, and the temperature distribution of slab, solidification process, and quality of slab are compared between before and after optimization. The results indicate that the surface temperature of slab is dropped equably after optimization, and the casting blank is cooling uniformly in the water springing zone so as to ensure better quality of the casting blank.