This paper presents the application of fuzzy inference on the issue of predicting crosstalk between interconnection wires. Effective electromagnetic interference parameters are selected as predictors from the pre-survey data, and the data are classified according to their statistical properties, and then fuzzy implication sentences are merged to determine the relationship between fuzzy implication set. Compared with the artificial neural network forecasting method,fuzzy inference forecasting method can not only make full use of existing experience and knowledge of experts, but also extract antomation summary and the new inference rules. The result of the example shows that the method is feasible.