The cellular automaton (CA) method is coupled with finite difference method to establish a stochastic nucleation and growth model. According to the actual production conditions, the solidification structure of continuous casting slab is simulated and the evolution law of the inner structure is reconstructed. It is showed that grain transformation is from equiaxed crystal to columnar crystal and then to equiaxed crystal. Thickness of three crystal layers are different in various production technological systems, thickness of surface equiaxed crystal and inner equiaxed crystal are reduced, and the results of the columnar crystal thickness are contrary, while casting speed and superheat are increasing. The results show well agreement with the stochastic nucleation, preferred growth, competitive growth and random orientation of grain.