Experiments of outburst coal’s gas seepage and deformation under cyclic loading of the stationary gas pressure and different confining pressures are made by “fluid-solid-heat coupling with axis servo seepage system of coal”. The results show that loading route has a significant effect on mechanical properties of coal sample. Although the complete stress-strain curves and one cyclic loading curve present similarity in the overall trend, the stress peak value of coal sample under cyclic loading is lower. Under cyclic loading, the stress-strain curves during loading and unloading don’t overlap. They connect to form a hysteretic loop. The permeability is in close relation with the damage deformation process of coal sample. Under cyclic loading, permeability is increasing during the unloading and decreasing during the loading. The permeability-strain curves during loading and unloading form a hysteretic loop, which is corresponding with the hysteretic loop of stress-strain curves of coal sample.