Three models of 3D cast-in-place RC frame structures are simulated in ABAQUS. In the three models, one represents the actual RC frame structure with monolithic slab, one represents the open frame structure used in structural design currently, which means truss structure at the stage of calculating internal forces of frame beams and columns, and the third one represents the open frame structure which takes into account some slab reinforcement in the rectangle section of frame beam to consider the slab participation in the flexural capacity of frame beam. By investigating the failure mode of these three models, the development of plastic hinges, the reinforcement stress of beam, column and slab in the models, the influence of monolithic slab to the bending resistance of beam end is studied. It shows that the existence of slab makes the failure mode of actual RC frame structure different from the design criteria of strong column weak beam. It also indicates that the slab participation in the bending resistance of beam end is not only expressed in the slab reinforcement but also in the structure integral performance. Besides, when using the effective flange width to consider the slab reinforcement participation, the structure integral performance, lateral displacement and other relevant factors should be taken into account.