Sinusoidal excitation shaking table test of full-scale reinforced asphalt isolation pier masonry building is carried out，and ANSYS is applied to set appropriate space finite element model，and then numerical simulation is given to the isolation pier.Comparison of both results of numerical simulation and shaking table test indicates that they agree well with each other.The result shows the applicability of finite element in reinforced asphalt isolation pier analysis.Seismic response analysis is given to the isolation and non-isolation model，and the result shows displacement of isolation layer is increased with the increase of input amplitude under same seismic excitation.The acceleration amplitude at the top of structure and story displacement of isolation model is less than that of non-isolation model，which indicates that the isolation layer has an excellent performance under seismic action，and it reduces the shear force of upper structure.